Salustri Antonietta

Inviato da SalustriAntonietta il Gio, 22/10/2009 - 09:59

Istologia BIO 17

Biography: My field of interest has been in somatic cell-oocyte interaction without interruptions. From 1977 to 1984 I was employed as Assistant Professor in Histology and Embryology at the University of L’Aquila and I studied the influence of follicle somatic cells on oocyte growth and maturation. In 1984 I moved to the University of Rome Tor Vergata where I became Associate Professor in Embryology in 1986 and Full Professor in 2002. During these years I worked in identifying endocrine and paracrine factors involved in extracellular matrix deposition by cumulus cells surrounding the oocyte. These studies provided the first evidence that oocyte soluble factors influence somatic cell response to gonadotropin stimuli. I also contributed with my research to identify cumulus matrix components essential for in vivo oocyte fertilization. Presently, I am involved in studying the role of inflammatory molecules in female mouse fertility. Publications 2000-2011 Ievoli E, Lindstedt R, Inforzato A, Camaioni A, Palone F, Day AJ, Mantovani A, Salvatori G, Salustri A. (2011) Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly. Matrix Biology, 2011 In Press, Uncorrected Proof, Available online 18 May 2011 doi:10.1016/j.matbio.2011.05.002 Nagyova E, Camaioni A, Scsukova S, Mlynarcikova A, Prochazka R, Nemcova L, Salustri A. (2011) Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis. Mol Reprod Dev. 2011 Mar 29. doi: 10.1002/mrd.21312. [Epub ahead of print] Bianchi E, Barbagallo F, Valeri C, Geremia R, Salustri A, De Felici M, Sette C. (2010) Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development. Hum Mol Genet., 19: 4886-4894. Inforzato A, Rivieccio V, Morreale AP, Bastone A, Salustri A, Scarchilli L, Verdolina A, Vincenti S, Gallo G, Chiapparono C, Pacello L, Numera E, Serlupi-Crescenzi O, Day AJ, Bottazzi B, Mantovani A, De Santis R, and Salvatori G. (2008) Structural Characterization of PTX3 Disulfide Bond Network and Its Multimeric Status in Cumulus Matrix Organization. J Biol Chem. 283:10147-10161. Nagyova E, Camaioni A, Prochazka R, Day AJ and Salustri A. (2008) Synthesis of tumor necrosis alpha-induced protein 6 in porcine preovulatory follicles: a study with A38 antibody. Biology of Reproduction 78:903-909. Scarchilli L., Camaioni A., Bottazzi B., Negri V., Doni A., Deban, L. , Bastone A., Salvatori G., Mantovani A., Siracusa G., and Salustri A. (2007) PTX3 Interacts with Inter-{alpha}-trypsin Inhibitor: IMPLICATIONS FOR HYALURONAN ORGANIZATION AND CUMULUS OOPHORUS EXPANSION. J Biol Chem. 282:30161-30170. Bottazzi B., Bastone A., Doni A., Garlanda C., Valentino S., Deban L., Maina V., Cotena A., Moalli F., Vago L., Salustri A., Romani L., Mantovani A. (2006) The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility. J Leukoc Biol 79:909-912. Russell D.L., and Salustri A. (2006) Extracellular matrix of the cumulus-oocyte complex. Semin Reprod Med. 24:217-227. Salustri A., Garlanda C., Hirsch E., De Acetis M., Maccagno A., Bottazzi B., Mahoney D.J., Day A.J., Siracusa G., Mantovani A. (2005) Role of Pentraxin 3 in Female Fertility. In: Hyaluronan: structure, metabolism, biological activities, therapeutic applications. (Balazs and Hascall, eds) MBI press, Edgewater, NJ, USA, pp. 719-724. ISBN: 0-9771359-0-X (2 volume set) Zhuo L., Salustri A., Atsumi F., Kawano M., Wu J., Shen L., Ogura A., Yasue H., Hascall V.C., Kimata K. (2005) Role of serum-derived hyaluronan-associated protein in the construction of cumulus matrix and oocyte maturation. In: Hyaluronan: structure, metabolism, biological activities, therapeutic applications. (Balazs and Hascall, eds), MBI press, Edgewater, NJ, USA pp. 731-735. ISBN: 0-9771359-0-X (2 volume set) Salustri A., Camaioni C., Scarchilli L., Negri V. (2005) Espressione genica nelle cellule del cumulo e selezione ovocitaria. In: Fisiologia della Riproduzione, CIC Edizioni Internazionali, Roma, , pp. 87-90.ISBN: 88-7141-721-6 Salustri A., Garlanda C, Hirsch E, De Acetis M, Maccagno A, Bottazzi B, Doni A, Bastone A, Mantovani G, Beck Peccoz P, Salvatori G, J. Mahoney D, Day AJ, Siracusa G, Romani L, Mantovani A. (2004) PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization. Development 131:1577-1586. Salustri A., Fulop C, Camaioni A. and Hascall V.C. (2004) Oocyte-granulosa cell interactions. In: The Ovary, second edition (Leung P.C.K. and Adashi E.Y., eds), Elsevier Academic Press, San Diego, pp. 131-138,. Nagyova E, Camaioni A, Prochazka R, Salustri A. (2004) Covalent Transfer of Heavy Chains of Inter-{alpha}-Trypsin Inhibitor Family Proteins to Hyaluronan in In Vivo and In Vitro Expanded Porcine Oocyte-Cumulus Complexes. Biology of Reproduction 71:1838-1843. Fulop C, Szanto S, Mukhopadhyay D, Bardos T, Kamath RV, Rugg MS, Day AJ, Salustri A, Hascall VC, Glant TT, Mikecz K. (2003) Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development 130:2253-2261. Zhuo L, Salustri A, Kimata K.A (2003) Physiological function of serum proteoglycan bikunin: the chondroitin sulfate moiety plays a central role. Glycoconjugate Journal 19:241-247. Di Giacomo M., Camaioni A. and Salustri A. Apoptosis and hyaluronan-enriched extracellular matrix degradation in cumulus cell-oocyte complex: implication in fertility. In: New Developments in Hyaluronan, (Kennedy F.G., Phillips G.O.P., Williams P.A.), Woodhead, Cambridge, (2002) pp.489-495. Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R, Maccagno A, Riva F, Bottazzi B, Peri G, Doni A, Vago L, Botto M, De Santis R, Carminati P, Siracusa G, Altruda F, Vecchi A, Romani L, Mantovani A. (2002) Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 420 (6912):182-186. D’Alessandris C., Canipari R., Di Giacomo M., Epifano O., Camaioni A., Siracusa G. and Salustri A. (2001) Control of mouse cumulus cell-oocyte complex integrity before and after ovulation: plasminogen activator synthesis and matrix degradation. Endocrinology 142: 3033-3039. Mukhopadhyay D., Hascall V.C., Day A.J., Salustri A. and Fulop C. (2001) Two distinct populations of tumor necrosis factor stimulated gene-6 protein in the extracellular matrix of expanded mouse cumulus cell-oocyte complexes. Archives of Biochemistry and Biophysics 394: 173-181. Salustri A., Canipari R., Camaioni A., D'Alessandris C., Di Giacomo M. and Epifano O. (2001) Oocyte and cumulus cell relationships. In: Ovulation Induction (Filicori M., Ed), pp. 49-53. Salustri A., Fulop C., Hascall V.C., Camaioni A. and Di Giacomo M. (2000) The Role of the oocyte in ovulation. In: Ovulation: Evolving Scientific and Clinical Concepts, (Adashi E.Y., ed), Serono Symposia, Springer-Verlag, New York, Serono Symposia, pp 67-75. Salustri A. (2000) Paracrine actions of oocytes in the mouse pre-ovulatory follicle. International Journal of Developmental Biology 44: 591-597.